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Karbidopa-levodopa (Sinemet) Description

Karbidopa-levodopa is a perfect remedy which is used to treat symptoms of Parkinson's disease caused by manganese poisoning, encephalitis, carbon monoxide poisoning. Levodopa is central nervous system agent. Carbidopa is decarboxylase inhibitor. Levodopa gives anti-Parkinson's effect and carbidopa work by protecting levodopa effectiveness.

Generic name of Karbidopa-levodopa is Levodopa and Carbidopa.

Karbidopa-levodopa is also known as Carbidopa-Levodopa, Parcopa, Syndopa.

Brand names of Karbidopa-levodopa are Karbidopa-levodopa, Parcopa, Karbidopa-levodopa CR, Stalevo.

Karbidopa-levodopa (Sinemet) Dosage

Karbidopa-levodopa is available in:

  • 10mg + 100mg Low Dosage
  • 25mg + 100mg Standard Dosage
  • 25mg + 250mg Increased Dosage

Karbidopa-levodopa is available in tablets (10mg + 100mg, 25mg + 100mg, 25mg + 250mg), orally disintegrating tablets, extended-release tablets orally.

Usually tablets and disintegrating tablets are taken 3-4 times a day. The extended-release tablets are usually taken 2-4 times a day. Take Karbidopa-levodopa before meal with water.

Do not take Karbidopa-levodopa if you are under 18.

Do not crush or chew it.

If you want to achieve most effective results do not stop taking Karbidopa-levodopa suddenly.

Karbidopa-levodopa (Sinemet) Missing of dose

Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.

Karbidopa-levodopa (Sinemet) Overdose

If you overdose Karbidopa-levodopa and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Karbidopa-levodopa overdosage: muscle twitches, inability to open the eyes.

Karbidopa-levodopa (Sinemet) Storage

Store at room temperature between 15 and 30 degrees C (59 and 86 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Karbidopa-levodopa (Sinemet) Side effects

Karbidopa-levodopa has its side effects. The most common are:

  • nausea
  • constipation
  • uncontrolled jerking or twitching
  • vomiting, insomnia
  • decreased appetite
  • diarrhea
  • extreme sweating
  • weakness
  • confusion
  • seeing things or hearing voices that do not exist (hallucinating)
  • migraine
  • nervousness
  • nightmares
  • dry mouth
  • lightheadedness
  • feeling drowsy

Less common but more serious side effects during taking Karbidopa-levodopa:

  • allergy reactions (urticaria, breathing difficulties, rash, and eruption)
  • difficulties with swallowing
  • tarry and black stools
  • pounding, fast, irregular heartbeat
  • depression
  • bloody vomit
  • thoughts of deated
  • blood in stools
  • symptoms of allergy reaction (hives, difficulties with breathing, rash, swelling, closing )
  • huskiness

Side effects manifestations are not only depend on medicine you are taking but also depend on your health state and on the other factors.

Karbidopa-levodopa (Sinemet) Contra-indications

Do not take Karbidopa-levodopa if you are allergic to Karbidopa-levodopa components.

Do not take Karbidopa-levodopa if you are pregnant, planning to become pregnant or breast-feeding.

Be careful using Karbidopa-levodopa if you take iron pills and vitamins containing iron; metoclopramide (such as Reglan); isoniazid (such as Nydrazid, INH); isocarboxazid (such as Marplan); phenytoin (such as Dilantin); antihistamines; risperidone (such as Risperdal); antidepressants (protriptyline (such as Vivactil), clomipramine (such as Anafranil), doxepin (such as Sinequan, Adapin), amitriptyline (such as Elavil), desipramine (such as Norpramin), trimipramine (such as Surmontil), amoxapine (such as Asendin), nortriptyline (such as Pamelor, Aventyl), imipramine (such as Tofranil); selegiline (such as Eldepryl); ipratropium (such as Atrovent); rasagiline (such as Azilect); haloperidol (such as Haldol); high blood pressure medicines; motion sickness, ulcers, irritable bowel disease, nausea, urinary problems, mental illness medications; papaverine (such as Pavabid), tranyllcypromine (such as Parnate) or phenelzine (such as Nardil).

It can be dangerous to use Karbidopa-levodopa if you suffer from or have a history of glaucoma, undiagnosed mole, melanoma, suspicious, phenylketonuria, mental illness; diabetes; heart attacks; asthma; bronchial asthma; endocrine disorder; emphysema; ulcers; active peptic ulcer; hormone problems; irregular heartbeat; kidney, liver, blood vessel, lung or heart disease.

Be careful with Karbidopa-levodopa if you are going to have a surgery.

Do not take Karbidopa-levodopa if you are under 18.

Avoid driving machine.

It can be dangerous to stop Karbidopa-levodopa taking suddenly.

Karbidopa-levodopa (Sinemet) Frequently asked questions

Q: What is Karbidopa-levodopa?

A: Karbidopa-levodopa is a perfect remedy which is used to treat symptoms of Parkinson's disease caused by manganese poisoning, encephalitis, carbon monoxide poisoning.

Q: What should I do in case of dose missing?

A: In case of dose missing you should take your tablet as soon as possible. Do not take double dosage. And if it is right time for the next dosage you should continue your regular schedule of Karbidopa-levodopa taking.

Q: What are Karbidopa-levodopa side effects?

A: Karbidopa-levodopa has its common side effects such as: nausea, constipation, uncontrolled jerking or twitching, vomiting, insomnia, decreased appetite, diarrhea, extreme sweating, weakness, confusion, seeing things or hearing voices that do not exist (hallucinating), migraine, nervousness, nightmares, dry mouth, lightheadedness, feeling drowsy. But in case of rejection of Karbidopa-levodopa ingredients you can experience more serious side effects: difficulties with swallowing, tarry and black stools, pounding, fast, irregular heartbeat, depression, bloody vomit, thoughts of death, red blood in stools, symptoms of allergy reaction (hives, difficulties with breathing, rash, swelling, closing ), huskiness.

Q: What are generic and brand names of Karbidopa-levodopa?

A: Generic name of Karbidopa-levodopa is Levodopa and Carbidopa. Brand names of Karbidopa-levodopa are Karbidopa-levodopa, Parcopa, Karbidopa-levodopa CR, Stalevo.

Q: In what way does it operate?

A: Levodopa is central nervous system agent. Carbidopa is decarboxylase inhibitor. Levodopa gives anti-Parkinson's effect and carbidopa work by protecting levodopa effectiveness.

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