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Dydrogesterone (Duphaston) Description

Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol.

Generic name of Dydrogesterone is Dydrogesterone.

Dydrogesterone is also known as Dydrogesterone.

Brand name of Dydrogesterone is Dydrogesterone.

Dydrogesterone (Duphaston) Dosage

Dydrogesterone is available in:

  • 10mg Standard Dosage

The dosage schemes below are meant as general recommendations. For optimal therapeutic effect, the dosages are to be adapted to the nature and severity of the disorder.

In irregular cycles due to endogenous progesterone deficiency

Dydrogesterone 5 to 10 mg is recommended especially in irregular cycles due to shortened luteal phase (ie pre-menopause). Treatment should be repeated for several cycles.

In secondary amenorrhoea

Administration of Dydrogesterone in combination with an estrogen is usually recommended as in these conditions endogenous progesterone deficiency is nearly always accompanied by estrogen deficiency. 0,05 mg ethinylestradiol is administered each day from the 1st to the 25th day of the cycle, and 5 mg Dydrogesterone is added twice daily from the 11th to the 25th day. Five days after the subsequent withdrawal bleeding, the same is repeated to imitate a natural cycle.

In dysfunctional uterine bleeding

The symptomatic treatment is aimed at stopping the bleeding and including a subsequent withdrawal bleeding.

To stop bleeding: Dydrogesterone 10 mg together with 0,10 mg ethinylestradiol twice daily for 5 to 7 days.

To prevent heavy bleedings: Dydrogesterone 5 mg twice daily from day 11 to day 25 of the cycle, if necessary, combined with an estrogen during the first half of the cycle.

In post-menopausal complaints

If for the symptomatic treatment of post-menopausal complaints estrogens are used (hormone replacement therapy A?A?A? HRT), Dydrogesterone 10 mg is used to counteract the effects of unopposed estrogens on the endometrium. A subsequent withdrawal bleeding is induced.

On continuous estrogen therapy: Dydrogesterone 10 mg twice daily during the first 12 to 14 days of each calendar month.

On cyclic estrogen therapy: Dydrogesterone 10 mg twice daily during the last 12 to 14 days of the treatment.

If you want to achieve most effective results do not stop taking Dydrogesterone suddenly.

Dydrogesterone (Duphaston) Missing of dose

Do not take double dose. If you miss a dose you should take it as soon as you remember about your missing. If it is the time for the next dose you should continue your regular dosing schedule.

Dydrogesterone (Duphaston) Overdose

If you overdose Dydrogesterone and you don't feel good you should visit your doctor or health care provider immediately. Symptoms of Dydrogesterone overdosage: diarrhea, stomach pain, hot and dry skin, confusion, uneven heart rate, extreme thirst, increased urination, leg discomfort, and muscle weakness or limp feeling.

Dydrogesterone (Duphaston) Storage

Store at room temperature below 25 degrees C (77 degrees F) away from moisture, light and heat. Throw away any unused medicine after the expiration date. Keep out of the reach of children.

Dydrogesterone (Duphaston) Side effects

Dydrogesterone has its side effects. The most common are:

  • gastro-intestinal disturbances
  • changes in libido
  • acne
  • fluid retention
  • mass gain
  • mental depression and breast changes, which may include discomfort or gynaecomastia

Less common but more serious side effects during taking Dydrogesterone:

  • allergy reactions (urticaria, breathing difficulties, rash, and eruption)
  • alterations in liver function tests
  • jaundice
  • breakthrough bleeding

Side effects manifestations are not only depend on medicine you are taking but also depend on your health state and on the other factors.

Dydrogesterone (Duphaston) Contra-indications

Do not take Dydrogesterone if you are allergic to Dydrogesterone components.

It is unknown how Dydrogesterone affects pregnant women or nursing mother.

Do not take Dydrogesterone if you have undiagnosed vaginal bleeding or a history of thromboembolic disorders.

Be careful with Dydrogesterone if you have cardiovascular, renal or hepatic impairment, diabetes mellitus, asthma, epilepsy and migraine, history of mental depression.

Drug interactions can result in unwanted side effects or prevent a medicine from doing its job. Some medicines or medical conditions may interact with this medicine. Inform your doctor or pharmacist of all prescription and over-the-counter medicine that you are taking.

Do not stop taking Dydrogesterone suddenly.

Dydrogesterone (Duphaston) Frequently asked questions

Q: What should I do if I miss a dose or overdose?

A: If you miss a dose you should take it as soon as you remember it. If it is the time for the next dose you should just continue your regular dosing schedule. Do not take double dose. If you overdose Dydrogesterone, you should just visit you doctor or health care provider immediately.

Q: What are generic and brand names of Dydrogesterone?

A: Generic name of Dydrogesterone is Dydrogesterone. Brand name of Dydrogesterone is Dydrogesterone.

Q: What is Dydrogesterone?

A: Dydrogesterone is an orally active progestogen which acts directly on the uterus, producing a complete secretory endometrium in an estrogen-primed uterus. At therapeutic levels, Dydrogesterone has no contraceptive effect as it does not inhibit or interfere with ovulation or the corpus luteum. Furthermore, Dydrogesterone is non-androgenic, non-estrogenic, non-corticoid, non-anabolic and is not excreted as pregnanediol.

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